BPDE-DNA, mAb 5D11 – 20 µg - HM5007-20UG
Catalog #
HM5007-20UG
133,00 €
Verwandte Produkte
A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representative PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic. The monoclonal antibody 5D11 recognizes BPDE-I-DNA (PAH-DNA).
| Datasheet URL | https://www.hycultbiotech.com/wp-content/uploads/2022/06/coa-tds_hm5007-20ug.pdf |
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| Quantity | 20ug |
| Species | n/a |
| Application | Flow cytometry, Immuno assays, Immuno fluorescence, Immuno precipitation, Paraffin sections |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
| References | 1. Santella, R et al; Monoclonal antibodies to DNA modified by benzo[a]pyrene diol epoxide. Carcinogenesis 1984, 5: 373 2. Zhang, YJ et al; Immunohistochemical detection of polycyclic aromatic hydrocarbon-DAN damage in human blood vessels of smokers and non-smokers. Atherosclerosis 1998, 140:325 3.-Rybicki, BA et al. Polycyclic aromatic hydrocarbon-DNA adducts in prostate cancer. Cencer Res 2004, 64: 8854 4. Maisonnette, C et al; Selective immunoclean-up followed by liquid chromatography for the monitoring of a biomarker of exposure to polycyclic aromatic hydrocarbons in urine at the ng l-1 level. J. Chromatogr A 2006, 1120:185 5. Jurisicova, A et al; Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. J Clin Invest 2007, 117: 3971 6. Shinmura, K et al. Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). J Pathol 2008, 216:365 7. Chen, K et al; Modulation of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. BBRC 2009, 383:151 8. Ji, G et al; Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. PLOS one 2010, 5:e13145 9. Abedi-ardekani, B et al; Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran. Gut 2010, 59:1178 10. Ye, F et al; Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-β2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A. Molecular cancer 2010, 9:93 |
| Disease | Tumor immunology |
| Application: | Flow cytometry Immuno assays Immuno fluorescence Immuno precipitation Paraffin sections |
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