C3/C3b, Human, mAb 755 – 100 µg - HM2072-100UG
Quantity
100 µg
Catalog #
HM2072-100UG
414,00 €
Exploring the Role of C3/C3b in Innate Immunity and Complement Activation
The complement system, a cornerstone of innate immunity, involves crucial components like C3/C3b. This key element is central to the classical, alternative, and lectin pathways of complement activation, highlighting its significance in immune defense mechanisms.
Synthesis and Abundance
The synthesis of C3, is tissue-specific and influenced by various stimulatory agents. As the most abundant protein in the complement system, C3 has significant serum protein levels, about 1.3 mg/ml. Understanding the synthesis and regulation of C3 helps in comprehending the dynamics of C3/C3b.
Disease and Immune Response
A deficiency in C3/C3b can lead to increased susceptibility to bacterial infections, underlining its protective role. In contrast, the deposition of C3 fragments, including C3/C3b, is observed in diseases like ulcerative colitis and chronic inflammatory bowel disease, indicating its role in immunopathology.
The Mechanism of C3/C3b Formation and Function
Upon activation of the complement system, enzymes cleave C3 into C3b (part of C3/C3b) and C3a. C3b binds to immune complexes and undergoes further cleavage into various fragments. Within the alternative pathway, C3b is essential for amplifying the immune response, highlighting the critical role in this process.
Not sure which C3 antibody to use?
With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision:
Go to our C3 researcher’s guide and choose the right antibody
The complement system, a cornerstone of innate immunity, involves crucial components like C3/C3b. This key element is central to the classical, alternative, and lectin pathways of complement activation, highlighting its significance in immune defense mechanisms.
Synthesis and Abundance
The synthesis of C3, is tissue-specific and influenced by various stimulatory agents. As the most abundant protein in the complement system, C3 has significant serum protein levels, about 1.3 mg/ml. Understanding the synthesis and regulation of C3 helps in comprehending the dynamics of C3/C3b.
Disease and Immune Response
A deficiency in C3/C3b can lead to increased susceptibility to bacterial infections, underlining its protective role. In contrast, the deposition of C3 fragments, including C3/C3b, is observed in diseases like ulcerative colitis and chronic inflammatory bowel disease, indicating its role in immunopathology.
The Mechanism of C3/C3b Formation and Function
Upon activation of the complement system, enzymes cleave C3 into C3b (part of C3/C3b) and C3a. C3b binds to immune complexes and undergoes further cleavage into various fragments. Within the alternative pathway, C3b is essential for amplifying the immune response, highlighting the critical role in this process.
Not sure which C3 antibody to use?
With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision:
Go to our C3 researcher’s guide and choose the right antibody
| Datasheet URL | https://www.hycultbiotech.com/wp-content/uploads/2022/06/Template-CoA-TDS-HM2072-20UG.pdf |
|---|---|
| Quantity | 100ug |
| Quantity | 100 µg |
| Species | human |
| Alias | Complement component 3 |
| Application | Immuno assays, Western blot |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
| References | 1. Klos, A et al; Detection of native human complement components C3 and C5 and their primary activation peptides C3a and C5a (anaphylatoxic peptides) by ELISAs with monoclonal antibodies. J Immunol Meth 1988, 111: 241 2. Hawlisch, H et al; Guinea pig C3 specific rabbit single chain Fv antibodies from bone marrow, spleen and blood derived phage libraries. J Immunol Meth 2000, 236: 117 3. Friebe, A et al; Immunomodulatory Effects of Inactivated Parapoxvirus Ovis (Orf Virus) on Human Peripheral Immune Cells: Induction of Cytokine Secretion in Monocytes and Th1-Like Cells |
| Disease | Infectious diseases, Nephrology |
| Application: | Immuno assays Western blot |
|---|