C3d, Human, mAb 3 – 100 µg - HM2198-100UG
Quantity
100 µg
Catalog #
HM2198-100UG
510,00 €
Exploring the Integral Role of C3d in the Complement System and Innate Immunity
The complement system is a vital component of innate immunity, with the third complement component, C3, playing a central role in the classical, alternative, and lectin pathways of complement activation. This article emphasizes the significance of C3 and its by-product, C3d, in immune system functioning.
The Diversity and Activation of C3 in Immune Responses
Activation products of the complement cascade, including C3d, contain unique neo-epitopes, which are absent in the native components. These neo-epitopes are crucial for the system’s response to pathogens. The synthesis of C3, from which C3d derives, is tissue-specific and adjusts in response to various stimulatory agents, demonstrating its adaptability in immune regulation.
C3 Abundance and the Implications of its Deficiency
C3 is notably the most abundant protein in the complement system, with serum levels around 1.3 mg/ml. Interestingly, an inherited deficiency of C3, and consequently C3d, predisposes individuals to more frequent bacterial infections, highlighting their importance in disease prevention.
In conditions like ulcerative colitis and chronic inflammatory bowel disease, the deposition of C3 and C3d in diseased mucosa has been observed, indicating their role in immunopathology.
The Proteolytic Journey
The journey of C3, leading to the formation of C3d, begins with its cleavage by C3-convertases into C3a and C3b. C3b, upon attaching to immune complexes, undergoes further cleavage into iC3b and C3f. The subsequent processing of iC3b results in C3c and C3dg. Notably, C3dg can be further cleaved into C3d and C3g. It is important to note that the formation of C3d, a crucial step in immune response modulation, does not occur in plasma.
Not sure which C3 antibody to use?
With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision:
Go to our C3 researcher’s guide and choose the right antibody
The complement system is a vital component of innate immunity, with the third complement component, C3, playing a central role in the classical, alternative, and lectin pathways of complement activation. This article emphasizes the significance of C3 and its by-product, C3d, in immune system functioning.
The Diversity and Activation of C3 in Immune Responses
Activation products of the complement cascade, including C3d, contain unique neo-epitopes, which are absent in the native components. These neo-epitopes are crucial for the system’s response to pathogens. The synthesis of C3, from which C3d derives, is tissue-specific and adjusts in response to various stimulatory agents, demonstrating its adaptability in immune regulation.
C3 Abundance and the Implications of its Deficiency
C3 is notably the most abundant protein in the complement system, with serum levels around 1.3 mg/ml. Interestingly, an inherited deficiency of C3, and consequently C3d, predisposes individuals to more frequent bacterial infections, highlighting their importance in disease prevention.
In conditions like ulcerative colitis and chronic inflammatory bowel disease, the deposition of C3 and C3d in diseased mucosa has been observed, indicating their role in immunopathology.
The Proteolytic Journey
The journey of C3, leading to the formation of C3d, begins with its cleavage by C3-convertases into C3a and C3b. C3b, upon attaching to immune complexes, undergoes further cleavage into iC3b and C3f. The subsequent processing of iC3b results in C3c and C3dg. Notably, C3dg can be further cleaved into C3d and C3g. It is important to note that the formation of C3d, a crucial step in immune response modulation, does not occur in plasma.
Not sure which C3 antibody to use?
With numerous options available, it is essential to select the right C3 antibody to ensure the success of your research. We designed a guide to assist you in making an informed decision:
Go to our C3 researcher’s guide and choose the right antibody
| Datasheet URL | https://www.hycultbiotech.com/wp-content/uploads/2022/06/Template-CoA-TDS-HM2198-20UG.pdf |
|---|---|
| Quantity | 100ug |
| Quantity | 100 µg |
| Species | human |
| Application | Immuno assays, Immuno precipitation, Western blot |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product. |
| References | 1. Lachmann, P et al; Three monoclonal antibodies to human C3. Immunology 1980, 41: 503 2. Lachmann, P et al; Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies. J Exp Med 1982, 156: 205 3. Lachmann, P et al; Use of monoclonal anti-C3 antibodies to characterise the fragments of C3 that are found on erythrocytes. Vox Sang 1983, 45: 367 4. Chaplin, H et al; Further studies of the C3g component of the alpha 2D fragment of human C3. Clin Exp Immunol 1983, 51: 639 |
| Disease | Infectious diseases, Nephrology |
| Application: | Immuno assays Immuno precipitation Western blot |
|---|
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