Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.In Vitro: Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells.In Vivo: Sterigmatocystine (ip- 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1.
|MCE Cat. No.||HY-N6725-5mg|
|Solubility||10 mM in DMSO|
|Clinical Information||No Development Reported|
|Pathway||Apoptosis-Anti-infection-Cell Cycle/DNA Damage-Anti-infection|