PROTAC BRAF-V600E degrader-1 - HY-137487
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Catalog #
HY-137487
Ab
238,00 €
PROTAC BRAF-V600E degrader-1 (compound 23) is a potent PROTAC BRAF-V600E degrader whlie no degradation activity against BRAF-WT. PROTAC BRAF-V600E degrader-1 exhibits Kd values of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS) and inhibits the growth of melanoma cells[1]. (In the molecular structure, target protein ligand: BI-882370 (HY-107779), red part; E3 ubiquitin enzyme ligand: Pomalidomide (HY-10984), blue part; PROTAC linker: G007-LK (HY-12438), black part.
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-137487/PROTAC-BRAF-V600E-degrader-1-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-Kinase/protease |
| CAS | 2417296-84-3 |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 1001.07 |
| Solubility | DMSO : 170 mg/mL (ultrasonic) |
| Clinical Information | No Development Reported |
| Target | PROTACs;Raf |
| Application: | Cancer-Kinase/protease |
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