Siramesine (hydrochloride) - HY-14221A
Room Temperature
Nur noch %1 verfügbar
Catalog #
HY-14221A
Ab
103,00 €
Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-14221A/Siramesine-hydrochloride-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| Alternative Names | Lu 28-179 (hydrochloride) |
| CAS | 224177-60-0 |
| Storage | 4°C (Powder, sealed storage, away from moisture) |
| MWT | 491.04 |
| Solubility | DMSO : ≥ 42 mg/mL |
| Clinical Information | No Development Reported |
| Target | Ferroptosis;Sigma Receptor |
| Application: | Cancer-programmed cell death |
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