GSK-J4 - HY-15648B
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Catalog #
HY-15648B
Ab
104,00 €
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1[1][2][3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis[4].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-15648B/GSK-J4-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| CAS | 1373423-53-0 |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 417.50 |
| Solubility | DMSO : 100 mg/mL (ultrasonic) |
| Clinical Information | No Development Reported |
| Target | Apoptosis;Histone Demethylase |
| Application: | Cancer-programmed cell death |
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