PROTAC TEAD degrader-1 - HY-158342
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Catalog #
HY-158342
Ab
868,00 €
PROTAC TEAD degrader-1 (Compound 27) is a PROTAC degrader for transcriptional enhanced associate domain (TEAD). PROTAC TEAD degrader-1 selectively degrades the Flag TEAD2 in a ubiquitin proteasome-dependent manner, with a DC50 of 54.1 nM in 293T cells, inhibits proliferation of NF2-deficient NCI-H226 with an IC50 of 0.21 μM, and regulates expressions of yes associated protein (YAP) target genes. (Pink: TEAD ligand (HY-158400); Black: linker (HY-W008474); Blue: E3 ligase ligand (HY-W087383))[1]
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-158342/PROTAC-TEAD-degrader-1-DataSheet-MedChemExpress.pdf |
|---|---|
| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| CAS | 3061498-57-2 |
| Storage | 4°C (Powder, protect from light, stored under nitrogen) |
| MWT | 822.83 |
| Solubility | DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
| Clinical Information | No Development Reported |
| Target | PROTACs;YAP |
| Application: | Cancer-programmed cell death |
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