PROTAC KRAS G12D degrader 1 - HY-161176
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Catalog #
HY-161176
Ab
486,00 €
PROTAC KRAS G12D degrader 1 is a selective PROTAC KRASG12D degrader. PROTAC KRAS G12D degrader 1 inhibits proliferation of KRASG12D-mutant cells and suppresses ERK phosphorylation. PROTAC KRAS G12D degrader 1 inhibits tumor growth in mice bearing AsPC-1 xenografts. PROTAC KRAS G12D degrader 1 can be used for the study of KRASG12D-driven cancers.(Pink: KRAS ligand (HY-175892), Blue: VHL Ligand (HY-112078), Black: Linker, E3 ligase ligand-linker conjugate (HY-175893))[1].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-161176/PROTAC-KRAS-G12D-degrader-1-DataSheet-MedChemExpress.pdf |
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| Shipping | Blue Ice |
| Application | Cancer-programmed cell death |
| CAS | 3033583-54-6 |
| Storage | -20°C, 3 years (Powder) |
| MWT | 1103.33 |
| Solubility | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
| Clinical Information | No Development Reported |
| Target | ERK;PROTACs;Ras |
| Application: | Cancer-programmed cell death |
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