Cardiomyocyte proliferation promoting agent-1 - HY-164254

Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), the E/Z mixture compound, is a cardiomyocyte proliferation promoting agent. GA-002 (single E configuration) is a LATS1 and LATS2 kinase inhibitor with IC50 values of 3.93 nM and 3.87 nM, respectively. GA-002 induces Hippo pathway-regulated gene, inhibits YAP/TAZ phosphorylation, and induces YAP nuclear translocation[1].