PROTAC YAP degrader-1 - HY-168016
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Catalog #
HY-168016
Ab
418,00 €
PROTAC YAP degrader-1 is a VHL-recruiting PROTAC degrader (DC50=8.2 μM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP/TEAD-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma[1].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-168016/PROTAC-YAP-degrader-1-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| CAS | 3058483-58-9 |
| Storage | 4°C (Powder, protect from light, stored under nitrogen) |
| MWT | 995.19 |
| Solubility | DMSO : 100 mg/mL (ultrasonic) |
| Clinical Information | No Development Reported |
| Target | PROTACs;YAP |
| Application: | Cancer-programmed cell death |
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