PROTAC c-Met degrader-1 - HY-168135
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Catalog #
HY-168135
Ab
671,00 €
PROTAC c-Met degrader-1 is a selective and orally active c-Met PROTAC degrader with a DC50 of 6.21 nM against c-Met. PROTAC c-Met degrader-1 induces CRBN-dependent ubiquitination and proteasomal degradation of c-Met. PROTAC c-Met degrader-1 induces G0/G1 phase arrest in c-Met-dependent cancer cells. PROTAC c-Met degrader-1 kills c-Met-dependent cancer cells. PROTAC c-Met degrader-1 inhibits tumor growth in animal models. PROTAC c-Met degrader-1 can be used for the research of gastric cancer[1].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-168135/PROTAC-c-Met-degrader-1-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| CAS | 3056647-52-7 |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 820.87 |
| Solubility | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
| Clinical Information | No Development Reported |
| Target | c-Met/HGFR;PROTACs |
| Application: | Cancer-programmed cell death |
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