PROTAC cGAS degrader-1 - HY-172208
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Catalog #
HY-172208
Ab
661,00 €
PROTAC cGAS degrader-1 (Compound TH35) is an effective and selective cGAS PROTAC degrader, with DC50 values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 can inhibit the activation of cGAS signaling induced by dsDNA. PROTAC cGAS degrader-1 has anti-inflammatory activity and can be used in the research of cGAS-related inflammatory diseases. (Pink: cGAS inhibitor (HY-133916); Black: Linker (HY-W411604); Blue: E3 ligase ligand (HY-43722))[1]
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-172208/PROTAC-cGAS-degrader-1-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | COVID-19-immunoregulation |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 714.60 |
| Solubility | DMSO : 100 mg/mL (ultrasonic) |
| Clinical Information | No Development Reported |
| Target | Cyclic GMP-AMP Synthase;PROTACs |
| Application: | COVID-19-immunoregulation |
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