ABT-737 - HY-50907
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Catalog #
HY-50907
Ab
86,00 €
ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research[1][2][3].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-50907/ABT-737-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| CAS | 852808-04-9 |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 813.43 |
| Solubility | DMSO : 66.67 mg/mL (ultrasonic;warming;heat to 60°C) |
| Clinical Information | No Development Reported |
| Target | Apoptosis;Autophagy;Bcl-2 Family;Mitophagy |
| Application: | Cancer-programmed cell death |
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