Taltirelin (acetate) - HY-B0596A
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Catalog #
HY-B0596A
Ab
62,00 €
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca2+ concentration (Ca2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue[1][2][3].
Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-B0596A/Taltirelin-acetate-DataSheet-MedChemExpress.pdf |
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Shipping | Blue Ice |
Application | Neuroscience-Neuromodulation |
Alternative Names | TA-0910 (acetate) |
CAS | 1549593-23-8 |
Storage | -20°C (Powder, sealed storage, away from moisture) |
MWT | 465.46 |
Solubility | DMSO : 125 mg/mL (ultrasonic) |
Clinical Information | Launched |
Target | Apoptosis;Thyroid Hormone Receptor |
Application: | Neuroscience-Neuromodulation |
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