Taltirelin (acetate) - HY-B0596A

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Catalog #
HY-B0596A
Ab 62,00 €
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca2+ concentration (Ca2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue[1][2][3].
Weitere Informationen
Datasheet URL http://file.medchemexpress.com/batch_PDF/HY-B0596A/Taltirelin-acetate-DataSheet-MedChemExpress.pdf
Shipping Blue Ice
Application Neuroscience-Neuromodulation
Alternative Names TA-0910 (acetate)
CAS 1549593-23-8
Storage -20°C (Powder, sealed storage, away from moisture)
MWT 465.46
Solubility DMSO : 125 mg/mL (ultrasonic)
Clinical Information Launched
Target Apoptosis;Thyroid Hormone Receptor
Applications
Application: Neuroscience-Neuromodulation

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