Thalidomide 5-fluoride - HY-W087383
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Catalog #
HY-W087383
Ab
26,00 €
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused 20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively[1][2].
| Datasheet URL | http://file.medchemexpress.com/batch_PDF/HY-W087383/Thalidomide-5-fluoride-DataSheet-MedChemExpress.pdf |
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| Shipping | Room Temperature |
| Application | Cancer-programmed cell death |
| CAS | 835616-61-0 |
| Storage | -20°C, 3 years; 4°C, 2 years (Powder) |
| MWT | 276.22 |
| Solubility | DMSO : 50 mg/mL (ultrasonic) |
| Clinical Information | No Development Reported |
| Target | Apoptosis;Autophagy;Ligands for E3 Ligase |
| Application: | Cancer-programmed cell death |
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