MBL, Human, mAb 3E7 – 100 µg - HM2061-100UG
Quantity
100 µg
Catalog #
HM2061-100UG
565,00 €
Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.
| Datasheet URL | https://www.hycultbiotech.com/wp-content/uploads/2022/06/coa-tds_hm2061-100ug.pdf |
|---|---|
| Quantity | 100ug |
| Quantity | 100 µg |
| Species | human |
| Alias | Mannan Binding Lectin, mannose- or mannan-binding protein, MBP |
| Application | Flow cytometry, Frozen sections, Functional studies, Immuno assays |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
| References | 1. Matsushita, M et al; Human mannose-binding protein is identical to a component of Ra-reactive factor. Biochem Biophys Res Commun 1992, 183: 645 2. Hisano, S et al; Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 2001, 38: 1082 3. Vries de, B et al; The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. Am J Pathol 2004, 165: 1677 4. Nauta, A et al; Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol 2003, 33 : 2853 5. Nauta, A et al ; Opsonization with C1q and Mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol 2004, 173: 3044 6. Imai, N et al; Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition, Nephrol. Dial. Transplant. 2006 21: 2589-2595. 7. Pol, P et al; Mannan-Binding Lectin Mediates Renal Ischemia/Reperfusion Injury Independent of Complement Activation; American Journal of Transplantation 2012; 12: 877 8. Shushimita, S et al; Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. PLoSONE 2015, 10: e0137795 9. Poppelaars, F et al; Strong predictive value of mannose‑binding lectin levels for cardiovascular risk of hemodialysis patients. J Transl Med 2016, 14:236 |
| Disease | Infectious diseases |
| Application: | Flow cytometry Frozen sections Functional studies Immuno assays |
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