Biotinylated Recombinant Human Notch 2 Protein - RP02462B
Catalog #
AB-RP02462B
710,00 €
Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
| Datasheet URL | https://abclonal.com/instructions/pdf/RP02462B |
|---|---|
| Quantity | 100ug |
| Alternative Names | NOTCH2,AGS2,HJCYS,hN2,notch 2 |
| Species | Human |
| Source | HEK293 cells |
| Purity | >95%byTris-BisPAGE;>95%bySEC-HPLC |
| Immunogen | Leu26-Gln530 |
| Storage | Store at -20℃. Store the lyophilized protein at -20℃ to -80℃ up to 1 year from the date of receipt. |After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |