Rabbit anti-Androgen Receptor, clone EP120 (Monoclonal) - MON3399

Androgen receptor (AR) is a member of the steroid receptor superfamily that is essential for the growth of prostate cancer cells. Ithas been reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Data suggest that growth factors and their downstream tyrosinekinases, which are elevated during hormone-ablation therapy, can induce tyrosine phosphorylation of AR. Such modification may be important for prostate tumor growth under androgen-depletedconditions. Cellular signaling occurs following androgen binding tothe AR and translocation to the nucleus. This activated complex associates with androgen-responsive elements contained in the DNAsequence of target genes, affecting the transcriptional activity of these genes.